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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:5834
Term: hyperforin
Definition: A cyclic terpene ketone that is a prenylated carbobicyclic acylphloroglucinol derivative produced by St. John's Wort, Hypericum perforatum.
Chemical ID: MESH:C001654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2affects bindingISORGD:691056480464CTDhyperforin binds to NR1I2 proteinPMID:27071811
Nr1i2increases activityISORGD:691056480464CTDhyperforin results in increased activity of NR1I2 proteinPMID:15856409 PMID:26187274
Nr1i2increases response to substanceISORGD:691056480464CTDNR1I2 protein results in increased susceptibility to hyperforinPMID:26920453
Nr1i2multiple interactionsISORGD:691056480464CTD[NR1I2 protein co-treated with hyperforin] results in decreased expression of SLC22A1 mRNA; [NR1I2 protein results in increased susceptibility to hyperforin] which results in decreased expression of SLC22A1 mRNA; hyperforin binds to and results in increased activity of NR1I2 protein; hyperforin promotes the reaction [NR1I2 protein results in decreased expression of SLC22A1 mRNA]; NR1I2 protein affects the reaction [hyperforin results in increased expression of CYP2C9 mRNA]; NR1I2 protein promotes the reaction [hyperforin results in increased abundance of Lipids]PMID:14600250 PMID:15630458 PMID:20079722 PMID:26920453
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