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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1617608
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcl15
Name: C-X-C motif chemokine ligand 15
Acc ID: CHEBI:5834
Term: hyperforin
Definition: A cyclic terpene ketone that is a prenylated carbobicyclic acylphloroglucinol derivative produced by St. John's Wort, Hypericum perforatum.
Chemical ID: MESH:C001654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl15increases expressionISOCXCL8 (Homo sapiens)6480464CTDhyperforin results in increased expression of CXCL8 mRNAPMID:15622447
Cxcl15increases secretionISOCXCL8 (Homo sapiens)6480464CTDhyperforin results in increased secretion of CXCL8 proteinPMID:15622447
Cxcl15multiple interactionsISOCXCL8 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [hyperforin results in increased expression of CXCL8 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [hyperforin results in increased secretion of CXCL8 protein]; hyperforin promotes the reaction [JUN protein binds to CXCL8 promoter]; SB 203580 inhibits the reaction [hyperforin results in increased secretion of CXCL8 protein]; U 0126 inhibits the reaction [hyperforin results in increased expression of CXCL8 mRNA]; U 0126 inhibits the reaction [hyperforin results in increased secretion of CXCL8 protein]PMID:15622447
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