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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3399
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkcz
Name: protein kinase C, zeta
Acc ID: CHEBI:582124
Term: myriocin
Definition: An amino acid-based antibiotic derived from certain thermophilic fungi; acts as a potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis. Myriocin also possesses immunosuppressant activity.
Chemical ID: MESH:C001996
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkczdecreases activityISORGD:7363626480464CTDthermozymocidin results in decreased activity of PRKCZ protein

PMID:31053639
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