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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344192
Species: Homo sapiens
RGD Object: Gene
Symbol: TNF
Name: tumor necrosis factor
Acc ID: CHEBI:581177
Term: agrimoniin
Definition: A dimeric hydrolysable tannin in which 2 moles of potentillin monomer are linked via a dehydrogalloyl group; an antitumor tannin of Agrimonia pilosa Ledeb., which induces interleukin-1.
Chemical ID: MESH:C052420
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFmultiple interactionsEXP 6480464CTDagrimoniin inhibits the reaction [TNF protein affects the localization of and results in increased activity of RELA protein]; agrimoniin inhibits the reaction [TNF protein results in increased activity of and results in increased secretion of CXCL8 protein]PMID:27473819
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