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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313391
Species: Homo sapiens
RGD Object: Gene
Symbol: IDH2
Name: isocitrate dehydrogenase (NADP(+)) 2
Acc ID: CHEBI:57885
Term: 3-dehydrocarnitine
Definition: An ammonium betaine that is the conjugate base of 3-dehydrocarnitinium; major species at pH 7.3.
Chemical ID: MESH:C103930
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IDH2increases abundanceISOIdh2 (Mus musculus)6480464CTDIDH2 protein mutant form results in increased abundance of 3-dehydrocarnitinePMID:27469509
IDH2multiple interactionsISOIdh2 (Mus musculus)6480464CTDTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 3-dehydrocarnitine]PMID:27469509
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