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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70370
Species: Homo sapiens
RGD Object: Gene
Symbol: AQP2
Name: aquaporin 2
Acc ID: CHEBI:5778
Term: hydrochlorothiazide
Definition: A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.
Chemical ID: MESH:D006852
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AQP2decreases expressionISOAqp2 (Rattus norvegicus)6480464CTDHydrochlorothiazide results in decreased expression of AQP2 mRNA; Hydrochlorothiazide results in decreased expression of AQP2 proteinPMID:17584643
AQP2multiple interactionsISOAqp2 (Rattus norvegicus)6480464CTDHydrochlorothiazide inhibits the reaction [Lithium results in decreased expression of AQP2 protein]PMID:15504936
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