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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733614
Species: Mus musculus
RGD Object: Gene
Symbol: Gsta3
Name: glutathione S-transferase, alpha 3
Acc ID: CHEBI:5693
Term: hexachlorophene
Definition: An organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union.
Chemical ID: MESH:D006582
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsta3multiple interactionsISOGSTA3 (Homo sapiens)6480464CTDHexachlorophene inhibits the reaction [GSTA3 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]PMID:23769903
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