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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1351073
Species: Homo sapiens
RGD Object: Gene
Symbol: SIAH1
Name: siah E3 ubiquitin protein ligase 1
Acc ID: CHEBI:5693
Term: hexachlorophene
Definition: An organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union.
Chemical ID: MESH:D006582
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SIAH1increases expressionEXP 6480464CTDHexachlorophene results in increased expression of SIAH1 mRNAPMID:16735606
SIAH1multiple interactionsEXP 6480464CTDSIAH1 protein promotes the reaction [Hexachlorophene results in increased degradation of CTNNB1 protein]PMID:16735606
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