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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3959
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vdr
Name: vitamin D receptor
Acc ID: CHEBI:5692
Term: hexachlorobenzene
Definition: A member of the class of chlorobenzenes that is benzene in which all of the hydrogens are replaced by chlorines. An agricultural fungicide introduced in the mid-1940s and formerly used as a seed treatment, its use has been banned since 1984 under the Stockholm Convention on Persistent Organic Pollutants.
Chemical ID: MESH:D006581
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vdrmultiple interactionsISOVdr (Mus musculus)6480464CTD[Hexachlorobenzene co-treated with Diethylnitrosamine] results in decreased expression of VDR protein; Cholecalciferol inhibits the reaction [[Hexachlorobenzene co-treated with Diethylnitrosamine] results in increased expression of VDR protein]PMID:28634113
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