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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:5692
Term: hexachlorobenzene
Definition: A member of the class of chlorobenzenes that is benzene in which all of the hydrogens are replaced by chlorines. An agricultural fungicide introduced in the mid-1940s and formerly used as a seed treatment, its use has been banned since 1984 under the Stockholm Convention on Persistent Organic Pollutants.
Chemical ID: MESH:D006581
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionEXP 6480464CTDHexachlorobenzene results in decreased expression of ESR1 proteinPMID:29277037
Esr1increases phosphorylationEXP 6480464CTDHexachlorobenzene results in increased phosphorylation of ESR1 proteinPMID:22245120
Esr1multiple interactionsEXP 6480464CTDHexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in decreased phosphorylation of ESR1 protein]; Methylnitrosourea inhibits the reaction [Hexachlorobenzene promotes the reaction [ESR1 protein binds to SRC protein]]PMID:22245120
Esr1decreases expressionISOESR1 (Homo sapiens)6480464CTDHexachlorobenzene results in decreased expression of ESR1 proteinPMID:19879930
Esr1increases expressionISOEsr1 (Mus musculus)6480464CTDHexachlorobenzene results in increased expression of ESR1 proteinPMID:28923513
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDHexachlorobenzene results in increased expression of ESR1 proteinPMID:35181438
Esr1increases phosphorylationISOESR1 (Homo sapiens)6480464CTDHexachlorobenzene results in increased phosphorylation of ESR1 proteinPMID:19879930 PMID:35181438
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDalpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of ESR1 protein]; ESR1 protein affects the reaction [[Hydrocarbons, Chlorinated co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Hexachlorobenzene] results in increased secretion of IGF1 protein]; Fulvestrant promotes the reaction [Hexachlorobenzene results in decreased expression of ESR1 protein]PMID:19879930 PMID:31923581 PMID:35181438
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