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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347215
Species: Homo sapiens
RGD Object: Gene
Symbol: TIMP1
Name: TIMP metallopeptidase inhibitor 1
Acc ID: CHEBI:5691
Term: Hexachloro-1,3-butadiene
Definition: An organochlorine compound that has formula C4Cl6.
Chemical ID: MESH:C001335
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TIMP1decreases expressionISOTimp1 (Rattus norvegicus)6480464CTDhexachlorobutadiene results in decreased expression of TIMP1 mRNAPMID:21905055
TIMP1increases expressionISOTimp1 (Rattus norvegicus)6480464CTDhexachlorobutadiene results in increased expression of TIMP1 mRNA; hexachlorobutadiene results in increased expression of TIMP1 proteinPMID:21259293 PMID:21905055
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