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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10451
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:5615
Term: halothane
Definition: A haloalkane comprising ethane having three flouro substituents at the 1-position as well as bromo- and chloro substituents at the 2-position.
Chemical ID: MESH:D006221
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1affects metabolic processingISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 protein affects the metabolism of HalothanePMID:9103523
Cyp2e1increases metabolic processingISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 protein results in increased metabolism of HalothanePMID:11684365 PMID:12464242
Cyp2e1increases oxidationISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 protein results in increased oxidation of HalothanePMID:10805064
Cyp2e1increases response to substanceISOCyp2e1 (Rattus norvegicus)6480464CTDCYP2E1 protein results in increased susceptibility to HalothanePMID:12803597
Cyp2e1multiple interactionsISOCYP2E1 (Homo sapiens)6480464CTDDisulfiram inhibits the reaction [CYP2E1 protein results in increased oxidation of Halothane]PMID:10805064
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