GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Drd2 | affects binding | EXP | | 6480464 | CTD | Haloperidol binds to DRD2 protein | PMID:12191584 PMID:1361536 PMID:9109525 | Drd2 | increases expression | EXP | | 6480464 | CTD | Haloperidol results in increased expression of DRD2; Haloperidol results in increased expression of DRD2 mRNA; Haloperidol results in increased expression of DRD2 protein | PMID:1351265 PMID:18295747 PMID:7878047 PMID:8115415 PMID:8200438 | Drd2 | multiple interactions | EXP | | 6480464 | CTD | [Haloperidol binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; cyclo(leucylglycine) inhibits the reaction [Haloperidol results in increased expression of DRD2 protein]; DRD2 protein affects the reaction [Haloperidol results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Haloperidol results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3B protein]; felbamate inhibits the reaction [Haloperidol affects the activity of DRD2 protein]; Haloperidol binds to and results in decreased activity of DRD2 protein; Haloperidol inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; Haloperidol inhibits the reaction [iodosulpride binds to DRD2 protein]; Haloperidol inhibits the reaction [Spiperone binds to DRD2 protein]; Haloperidol promotes the reaction [Dopamine binds to DRD2 protein]; zinc chloride inhibits the reaction [Haloperidol binds to DRD2 protein] | PMID:10936494 PMID:11927170 PMID:1380082 PMID:15716360 PMID:16033416 PMID:16144542 PMID:7845605 PMID:7878047 PMID:8115415 PMID:9109525 | Drd2 | affects activity | ISO | DRD2 (Homo sapiens) | 6480464 | CTD | Haloperidol affects the activity of DRD2 protein | PMID:23611293 | Drd2 | affects binding | ISO | Drd2 (Mus musculus) | 6480464 | CTD | Haloperidol binds to DRD2; Haloperidol binds to DRD2 protein; Haloperidol binds to DRD2 protein alternative form | PMID:12476322 PMID:8794996 PMID:9808703 | Drd2 | affects binding | ISO | DRD2 (Homo sapiens) | 6480464 | CTD | DRD2 protein binds to Haloperidol; DRD2 protein binds to Haloperidol analog; Haloperidol binds to DRD2 protein | PMID:11997696 PMID:14552778 PMID:20361897 | Drd2 | affects response to substance | ISO | Drd2 (Mus musculus) | 6480464 | CTD | DRD2 affects the susceptibility to Haloperidol; DRD2 protein affects the susceptibility to Haloperidol | PMID:10720636 PMID:11172060 | Drd2 | increases expression | ISO | Drd2 (Mus musculus) | 6480464 | CTD | Haloperidol results in increased expression of DRD2 protein | PMID:2945998 | Drd2 | increases expression | ISO | DRD2 (Homo sapiens) | 6480464 | CTD | Haloperidol results in increased expression of DRD2 mRNA; Haloperidol results in increased expression of DRD2 protein | PMID:20730801 | Drd2 | multiple interactions | ISO | Drd2 (Mus musculus) | 6480464 | CTD | [Haloperidol binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Ethanol; [Haloperidol results in increased expression of DRD2 protein] which results in decreased susceptibility to Pentobarbital; Haloperidol binds to and results in decreased activity of DRD2 protein | PMID:19120057 PMID:2945998 | Drd2 | multiple interactions | ISO | DRD2 (Homo sapiens) | 6480464 | CTD | Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 mRNA]; Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 protein] | PMID:20730801 | |
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