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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dhfr
Name: dihydrofolate reductase
Acc ID: CHEBI:553473
Term: ceftizoxime
Definition: A parenteral third-generation cephalosporin, bearing a 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino group at the 7beta-position.
Chemical ID: MESH:D015296
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dhfrdecreases activityISODHFR (Homo sapiens)6480464CTDCeftizoxime results in decreased activity of DHFR proteinPMID:25418905
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