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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61959
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Txnrd1
Name: thioredoxin reductase 1
Acc ID: CHEBI:5516
Term: sodium aurothiomalate
Definition: A variable mixture of the mono- and di-sodium salts of aurothiomalic acid. It is used for treatment of rheumatoid arthritis.
Chemical ID: MESH:D006052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Txnrd1decreases activityEXP 6480464CTDGold Sodium Thiomalate results in decreased activity of TXNRD1 proteinPMID:16510263
Txnrd1multiple interactionsISOTxnrd1 (Mus musculus)6480464CTDGold Sodium Thiomalate inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]PMID:17229725
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