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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:5516
Term: sodium aurothiomalate
Definition: A variable mixture of the mono- and di-sodium salts of aurothiomalic acid. It is used for treatment of rheumatoid arthritis.
Chemical ID: MESH:D006052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6affects response to substanceISORGD:108026480464CTDIL6 protein affects the susceptibility to Gold Sodium Thiomalate

PMID:19077085
Il6decreases expressionISORGD:13525826480464CTDGold Sodium Thiomalate results in decreased expression of IL6 mRNA Gold Sodium Thiomalate results in decreased expression of IL6 protein

PMID:19192274
Il6multiple interactionsISORGD:108026480464CTDIL6 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]

PMID:19077085
Il6multiple interactionsISORGD:13525826480464CTD[Gold Sodium Thiomalate co-treated with mercury nitrate analog] results in increased expression of IL6 protein

PMID:11824965
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