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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737102
Species: Homo sapiens
RGD Object: Gene
Symbol: COMT
Name: catechol-O-methyltransferase
Acc ID: CHEBI:545959
Term: homovanillic acid
Definition: A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.
Chemical ID: MESH:D006719
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
COMTmultiple interactionsEXP 6480464CTD[tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic AcidPMID:11793163
COMTmultiple interactionsISOComt (Rattus norvegicus)6480464CTD[tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic AcidPMID:15190105 PMID:16012872
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