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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730944
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCB11
Name: ATP binding cassette subfamily B member 11
Acc ID: CHEBI:5384
Term: glipizide
Definition: An N-sulfonylurea that is glyburide in which the (5-chloro-2-methoxybenzoyl group is replaced by a (5-methylpyrazin-2-yl)carbonyl group. An oral hypoglycemic agent, it is used in the treatment of type 2 diabetes mellitus.
Chemical ID: MESH:D005913
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCB11decreases activityEXP 6480464CTDGlipizide results in decreased activity of ABCB11 proteinPMID:24014644
ABCB11multiple interactionsEXP 6480464CTDGlipizide inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]PMID:24014644
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