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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:53753
Term: triolein
Definition: A triglyceride formed by esterification of the three hydroxy groups of glycerol with oleic acid. Triolein is one of the two components of Lorenzo's oil.
Chemical ID: MESH:D014304
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:694746480464CTDTriolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]], Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of SREBF1 protein]]

PMID:15066988
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.