Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737312
Species: Homo sapiens
RGD Object: Gene
Symbol: AGER
Name: advanced glycosylation end-product specific receptor
Acc ID: CHEBI:53556
Term: toluene 2,4-diisocyanate
Definition: A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.
Chemical ID: MESH:D014051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AGERincreases expressionEXP 6480464CTDToluene 2,4-Diisocyanate results in increased expression of AGER proteinPMID:33075463
AGERmultiple interactionsEXP 6480464CTDAGER protein affects the reaction [Toluene 2,4-Diisocyanate analog affects the localization of CTNNB1 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein]; pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein]PMID:30261222 PMID:33075463
AGERincreases expressionISOAger (Mus musculus)6480464CTDToluene 2,4-Diisocyanate results in increased expression of AGER proteinPMID:28329851 PMID:30261222 PMID:33075463
AGERmultiple interactionsISOAger (Mus musculus)6480464CTDFPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein]; pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein]PMID:28329851 PMID:30261222 PMID:33075463
Go Back to source page   Continue to Ontology report