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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69008
Species: Homo sapiens
RGD Object: Gene
Symbol: IL13
Name: interleukin 13
Acc ID: CHEBI:53556
Term: toluene 2,4-diisocyanate
Definition: A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.
Chemical ID: MESH:D014051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL13increases expressionISOIl13 (Mus musculus)6480464CTDToluene 2,4-Diisocyanate results in increased expression of IL13 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL13 proteinPMID:11243917 PMID:15590890 PMID:16940033 PMID:17015710 PMID:17641053 PMID:19428947 PMID:20219652 PMID:30017638 PMID:30261222
IL13increases secretionISOIl13 (Mus musculus)6480464CTDToluene 2,4-Diisocyanate results in increased secretion of IL13 proteinPMID:17693426 PMID:28329851 PMID:30517707 PMID:33075463
IL13multiple interactionsISOIl13 (Mus musculus)6480464CTD2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 mRNA]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]; Methoxychlor promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; Pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]; Rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL13 protein]PMID:15590890 PMID:17015710 PMID:28329851 PMID:30017638 PMID:30261222 PMID:30517707 PMID:33075463
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