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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61995
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pten
Name: phosphatase and tensin homolog
Acc ID: CHEBI:53556
Term: toluene 2,4-diisocyanate
Definition: A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.
Chemical ID: MESH:D014051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptenmultiple interactionsISOPten (Mus musculus)6480464CTDPTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]; PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A protein]; PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein]; Toluene 2,4-Diisocyanate results in decreased expression of and results in decreased activity of PTEN proteinPMID:17982072
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