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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737517
Species: Homo sapiens
RGD Object: Gene
Symbol: STAT3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:53509
Term: erlotinib hydrochloride
Definition: The hydrochloride salt of erlotinib.
Chemical ID: MESH:D000069347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
STAT3decreases expressionEXP 6480464CTDErlotinib Hydrochloride results in decreased expression of STAT3 protein modified formPMID:30136359
STAT3decreases response to substanceEXP 6480464CTDSTAT3 mRNA results in decreased susceptibility to Erlotinib HydrochloridePMID:23125191
STAT3increases phosphorylationEXP 6480464CTDErlotinib Hydrochloride results in increased phosphorylation of STAT3 proteinPMID:23894143
STAT3increases response to substanceEXP 6480464CTDSTAT3 mutant form results in increased susceptibility to Erlotinib HydrochloridePMID:23894143
STAT3multiple interactionsEXP 6480464CTD[Betulinic Acid co-treated with Erlotinib Hydrochloride] results in decreased expression of STAT3 protein modified form; [Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased phosphorylation of STAT3 protein]PMID:23894143 PMID:30136359
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