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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:53063
Term: 2,4,6-trinitrobenzenesulfonic acid
Definition: The arenesulfonic acid that is benzenesulfonic acid with three nitro substituents in the 2-, 4- and 6-positions.
Chemical ID: MESH:D014302
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6increases expressionEXP 6480464CTDTrinitrobenzenesulfonic Acid results in increased expression of IL6; Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA; Trinitrobenzenesulfonic Acid results in increased expression of IL6 proteinPMID:18079364 PMID:19998380 PMID:21070844 PMID:22410118 PMID:30503585 PMID:31428839 PMID:33522063 PMID:35290143
Il6multiple interactionsEXP 6480464CTDChalcones inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Chalcones inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]; cinnamaldehyde inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]; hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]; Hydroxamic Acids analog promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Iridoid Glycosides inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]; Sulfur Dioxide inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]PMID:21070844 PMID:22410118 PMID:30503585 PMID:31428839 PMID:33522063 PMID:35290143
Il6decreases expressionISOIl6 (Mus musculus)6480464CTDTrinitrobenzenesulfonic Acid results in decreased expression of IL6 mRNAPMID:25307695
Il6increases expressionISOIl6 (Mus musculus)6480464CTDTrinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA; Trinitrobenzenesulfonic Acid results in increased expression of IL6 proteinPMID:17375199 PMID:18200517 PMID:19956958 PMID:20923188 PMID:21829567 PMID:22060784 PMID:23027085 PMID:23596210 PMID:23747339 PMID:25472953 PMID:25576893
Il6multiple interactionsISOIl6 (Mus musculus)6480464CTDCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Huangqin-Tang inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; icilin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]; lancemaside A inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]; notoginsenoside R1 inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]; soyasaponin Ab inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]; soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]PMID:18200517 PMID:19956958 PMID:20923188 PMID:22060784 PMID:23596210 PMID:25472953 PMID:25576893
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