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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3870
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tlr4
Name: toll-like receptor 4
Acc ID: CHEBI:53053
Term: 1-chloro-2,4,6-trinitrobenzene
Definition: The C-nitro compound that is chlorobenzene with three nitro substituents in the 2-, 4- and 6-positions.
Chemical ID: MESH:D010853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tlr4increases response to substanceISOTlr4 (Mus musculus)6480464CTDTLR4 protein results in increased susceptibility to Picryl ChloridePMID:18725520
Tlr4multiple interactionsISOTlr4 (Mus musculus)6480464CTDTLR2 protein affects the reaction [TLR4 protein results in increased susceptibility to Picryl Chloride]PMID:18725520
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