GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il1b | increases cleavage | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Picryl Chloride results in increased cleavage of IL1B protein | PMID:17429439 | Il1b | increases expression | ISO | Il1b (Mus musculus) | 6480464 | CTD | Picryl Chloride results in increased expression of IL1B protein | PMID:15734285 PMID:16442096 | Il1b | increases expression | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Picryl Chloride results in increased expression of IL1B protein | PMID:18854230 | Il1b | multiple interactions | ISO | Il1b (Mus musculus) | 6480464 | CTD | [Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL1B protein; Cyclosporine inhibits the reaction [Picryl Chloride results in increased expression of IL1B protein]; PPARA protein affects the reaction [[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL1B protein]; Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL1B protein]; Rolipram inhibits the reaction [Picryl Chloride results in increased expression of IL1B protein] | PMID:16442096 PMID:17371993 | Il1b | multiple interactions | ISO | IL1B (Homo sapiens) | 6480464 | CTD | 4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)cyclohexanecarboxylic acid inhibits the reaction [Picryl Chloride results in increased expression of IL1B protein]; CASP1 protein promotes the reaction [Picryl Chloride results in increased cleavage of IL1B protein] | PMID:17429439 PMID:18854230 | | ||||||||||||||||||||||
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