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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:53001
Term: nickel sulfate
Definition: A metal sulfate having nickel(2+) as the metal ion.
Chemical ID: MESH:C029938
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionISOBax (Mus musculus)6480464CTDnickel sulfate results in increased expression of BAX proteinPMID:23317420
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDnickel sulfate results in increased expression of BAX mRNA; nickel sulfate results in increased expression of BAX proteinPMID:35499276
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDsesamin inhibits the reaction [nickel sulfate results in increased expression of BAX protein]PMID:23317420
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDpyrazolanthrone inhibits the reaction [nickel sulfate results in increased expression of BAX protein]; SB 203580 inhibits the reaction [nickel sulfate results in increased expression of BAX protein]PMID:35499276
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