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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551988
Species: Mus musculus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase family, member 1
Acc ID: CHEBI:53001
Term: nickel sulfate
Definition: A metal sulfate having nickel(2+) as the metal ion.
Chemical ID: MESH:C029938
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDnickel sulfate results in increased cleavage of PARP1 proteinPMID:19135467
Parp1increases cleavageISOParp1 (Rattus norvegicus)6480464CTDnickel sulfate results in increased cleavage of PARP1 proteinPMID:19135467
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTD3-aminobenzamide inhibits the reaction [PARP1 protein results in increased susceptibility to [Potassium Dichromate co-treated with nickel sulfate]]; nickel sulfate inhibits the reaction [Potassium Dichromate results in increased cleavage of and results in increased activity of PARP1 protein]; nickel sulfate results in increased cleavage of and results in increased activity of PARP1 protein; PARP1 protein results in increased susceptibility to [Potassium Dichromate co-treated with nickel sulfate]; Potassium Dichromate inhibits the reaction [nickel sulfate results in increased cleavage of and results in increased activity of PARP1 protein]PMID:20493934
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