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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735711
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP1A2
Name: cytochrome P450 family 1 subfamily A member 2
Acc ID: CHEBI:5296
Term: gemfibrozil
Definition: An aromatic ether that has formula C15H22O3.
Chemical ID: MESH:D015248
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP1A2decreases activityEXP 6480464CTDGemfibrozil results in decreased activity of CYP1A2 proteinPMID:26599973
CYP1A2multiple interactionsEXP 6480464CTD[Gemfibrozil results in decreased activity of CYP1A2 protein] which results in decreased metabolism of AmodiaquinePMID:26599973
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