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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737596
Species: Homo sapiens
RGD Object: Gene
Symbol: RAF1
Name: Raf-1 proto-oncogene, serine/threonine kinase
Acc ID: CHEBI:5292
Term: geldanamycin
Definition: An ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria.
Chemical ID: MESH:C001277
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RAF1decreases expressionEXP 6480464CTDgeldanamycin results in decreased expression of RAF1 proteinPMID:24450340
RAF1multiple interactionsEXP 6480464CTDgeldanamycin results in decreased expression of and results in decreased phosphorylation of RAF1 proteinPMID:19167484
RAF1increases expressionISORaf1 (Mus musculus)6480464CTDgeldanamycin results in increased expression of RAF1 proteinPMID:8816498
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