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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733190
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA4
Name: heat shock protein family A (Hsp70) member 4
Acc ID: CHEBI:5292
Term: geldanamycin
Definition: An ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria.
Chemical ID: MESH:C001277
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA4increases expressionEXP 6480464CTDgeldanamycin results in increased expression of HSPA4 mRNA; geldanamycin results in increased expression of HSPA4 proteinPMID:16311509 PMID:26705709
HSPA4multiple interactionsEXP 6480464CTD[geldanamycin results in increased expression of HSPA4 protein] which results in decreased susceptibility to DoxorubicinPMID:16311509
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