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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352934
Species: Homo sapiens
RGD Object: Gene
Symbol: DDX3X
Name: DEAD-box helicase 3 X-linked
Acc ID: CHEBI:5292
Term: geldanamycin
Definition: An ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria.
Chemical ID: MESH:C001277
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DDX3Xincreases degradationEXP 6480464CTDgeldanamycin results in increased degradation of DDX3X proteinPMID:30821613
DDX3Xincreases expressionEXP 6480464CTDgeldanamycin results in increased expression of DDX3X mRNAPMID:26705709
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