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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318780
Species: Homo sapiens
RGD Object: Gene
Symbol: CSK
Name: C-terminal Src kinase
Acc ID: CHEBI:5292
Term: geldanamycin
Definition: An ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria.
Chemical ID: MESH:C001277
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CSKdecreases activityISOCsk (Mus musculus)6480464CTDgeldanamycin results in decreased activity of CSK proteinPMID:9664232
CSKmultiple interactionsISOCsk (Mus musculus)6480464CTDgeldanamycin inhibits the reaction [CSK protein results in increased susceptibility to Tetrachlorodibenzodioxin]; geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CSK protein binds to AHR protein]]PMID:9664232
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