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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1562456
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Skp2
Name: S-phase kinase associated protein 2
Acc ID: CHEBI:52722
Term: lactacystin
Definition: L-Cysteine substituted at nitrogen by an acetyl group and at sulfur by a substituted-lactam carbonyl group.
Chemical ID: MESH:C067713
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Skp2decreases expressionISOSKP2 (Homo sapiens)6480464CTDlactacystin results in decreased expression of SKP2 proteinPMID:23029392
Skp2multiple interactionsISOSKP2 (Homo sapiens)6480464CTDlactacystin inhibits the reaction [Estradiol results in increased expression of SKP2 protein]PMID:23029392
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