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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733473
Species: Homo sapiens
RGD Object: Gene
Symbol: IRS1
Name: insulin receptor substrate 1
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IRS1decreases degradationEXP 6480464CTDBortezomib results in decreased degradation of IRS1 proteinPMID:16227402
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