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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621375
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ikbkb
Name: inhibitor of nuclear factor kappa B kinase subunit beta
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ikbkbdecreases expressionISOIKBKB (Homo sapiens)6480464CTDBortezomib results in decreased expression of IKBKB mRNAPMID:20471514
Ikbkbmultiple interactionsISOIKBKB (Homo sapiens)6480464CTDBortezomib promotes the reaction [abexinostat results in decreased expression of IKBKB mRNA]; IKBKB protein affects the reaction [Bortezomib results in increased phosphorylation of and results in increased degradation of NFKBIA protein]PMID:19417023 PMID:24085292
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