GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk3 | decreases activity | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | Bortezomib results in decreased activity of MAPK3 protein | PMID:18445700 | Mapk3 | increases expression | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | Bortezomib results in increased expression of MAPK3 protein modified form | PMID:15039284 | Mapk3 | increases phosphorylation | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | Bortezomib results in increased phosphorylation of MAPK3 protein | PMID:20701607 | Mapk3 | multiple interactions | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | [Bortezomib co-treated with Butyrates] results in decreased expression of MAPK3 protein; [Bortezomib co-treated with panobinostat] results in decreased activity of MAPK3 protein; [Bortezomib co-treated with vorinostat] results in decreased expression of MAPK3 protein; alvocidib inhibits the reaction [Bortezomib results in increased expression of MAPK3 protein modified form]; Bortezomib promotes the reaction [Curcumin results in decreased phosphorylation of MAPK3 protein]; lapatinib inhibits the reaction [Bortezomib results in increased phosphorylation of MAPK3 protein] | PMID:12893773 PMID:15039284 PMID:18445700 PMID:19383353 PMID:20701607 | |
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