GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ERN1 | decreases response to substance | EXP | | 6480464 | CTD | ERN1 results in decreased susceptibility to Bortezomib | PMID:16357177 | ERN1 | multiple interactions | EXP | | 6480464 | CTD | [BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in increased expression of ERN1 mRNA; Bortezomib affects the reaction [ricolinostat affects the phosphorylation of ERN1 protein] | PMID:22262760 PMID:25522274 | |
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