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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359266
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pmaip1
Name: phorbol-12-myristate-13-acetate-induced protein 1
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13474266480464CTDBortezomib results in decreased expression of PMAIP1 mRNA

PMID:25913414
increases expressionISORGD:13474266480464CTDBortezomib results in increased expression of PMAIP1 mRNA, Bortezomib results in increased expression of PMAIP1 protein

PMID:16024631, PMID:16166592, PMID:16928686, PMID:17898295, PMID:18534018, PMID:18641367, PMID:18790767, PMID:20022965, PMID:20051518, PMID:20977926
increases response to substanceISORGD:13474266480464CTDPMAIP1 protein results in increased susceptibility to Bortezomib, PMAIP1 results in increased susceptibility to Bortezomib

PMID:16166592, PMID:16928686
multiple interactionsISORGD:13474266480464CTD[arsenic trioxide co-treated with Bortezomib] results in decreased expression of PMAIP1 mRNA, [Bortezomib co-treated with arsenic trioxide] results in increased expression of PMAIP1 protein, [Bortezomib co-treated with vorinostat] results in increased expression of PMAIP1 protein, [nutlin 3 co-treated with Bortezomib] results in increased expression of PMAIP1 protein, ATF3 mutant form promotes the reaction [Bortezomib results in increased expression of PMAIP1 mRNA], ATF4 mutant form inhibits the reaction [Bortezomib results in increased expression of PMAIP1 mRNA], ATF4 mutant form inhibits the reaction [Bortezomib results in increased expression of PMAIP1 protein], Bortezomib promotes the reaction [ATF4 protein binds to PMAIP1 promoter], MYC protein promotes the reaction [Bortezomib results in increased expression of PMAIP1 protein], PMAIP1 protein promotes the reaction [[Bortezomib co-treated with arsenic trioxide] results in increased activity of CASP3 protein], PMAIP1 protein promotes the reaction [[Bortezomib co-treated with vorinostat] results in increased activity of CASP4 protein]

PMID:18641367, PMID:20022965, PMID:20850924, PMID:21518486, PMID:25913414
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.