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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317580
Species: Homo sapiens
RGD Object: Gene
Symbol: TNFRSF10A
Name: TNF receptor superfamily member 10a
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFRSF10Aaffects expressionEXP 6480464CTDBortezomib affects the expression of TNFRSF10A mRNA; Bortezomib affects the expression of TNFRSF10A proteinPMID:17327374 PMID:17510429
TNFRSF10Adecreases expressionEXP 6480464CTDBortezomib results in decreased expression of TNFRSF10A proteinPMID:19922463
TNFRSF10Aincreases expressionEXP 6480464CTDBortezomib results in increased expression of TNFRSF10A proteinPMID:12902978 PMID:17327374 PMID:17620439 PMID:17875785
TNFRSF10Aincreases localizationEXP 6480464CTDBortezomib results in increased localization of TNFRSF10A proteinPMID:17326159
TNFRSF10Amultiple interactionsEXP 6480464CTD[Bortezomib co-treated with arsenic trioxide] results in increased expression of TNFRSF10A protein; [Bortezomib results in increased localization of TNFRSF10A protein] promotes the reaction [Bortezomib results in increased susceptibility to and results in increased activity of TNFSF10 protein]; Brefeldin A inhibits the reaction [Bortezomib results in increased localization of TNFRSF10A protein]PMID:17326159 PMID:24377552
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