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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:692136480464CTD[Arsenic Trioxide co-treated with Bortezomib] results in decreased expression of ESR2 mRNA, Bortezomib binds to and results in decreased activity of ESR2 protein, Bortezomib inhibits the reaction [Estradiol results in increased activity of ESR2 protein]

PMID:25752796, PMID:25913414, PMID:30818834
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.