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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1620890
Species: Mus musculus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP-binding cassette, sub-family B member 1A
Acc ID: CHEBI:5262
Term: galangin
Definition: A 7-hydroxyflavonol with additional hydroxy groups at positions 3 and 5 respectively; a growth inhibitor of breast tumor cells.
Chemical ID: MESH:C037032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aincreases activityISOABCB1 (Homo sapiens)6480464CTDgalangin results in increased activity of ABCB1 proteinPMID:34217736
Abcb1aincreases expressionISOABCB1 (Homo sapiens)6480464CTDgalangin results in increased expression of ABCB1 mRNA; galangin results in increased expression of ABCB1 proteinPMID:26238175 PMID:34217736
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTDgalangin inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; Verapamil promotes the reaction [galangin results in increased activity of ABCB1 protein]PMID:34217736
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