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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:5262
Term: galangin
Definition: A 7-hydroxyflavonol with additional hydroxy groups at positions 3 and 5 respectively; a growth inhibitor of breast tumor cells.
Chemical ID: MESH:C037032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7368326480464CTDgalangin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein], galangin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]

PMID:25625231
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.