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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736430
Species: Mus musculus
RGD Object: Gene
Symbol: Arg1
Name: arginase, liver
Acc ID: CHEBI:52497
Term: maneb
Definition: A polymeric complex of manganese with the ethylene bis(dithiocarbamate) anionic ligand. An agrochemical fungicide, it is used to control a variety of diseases including blight, leaf spot, rust, downy mildew and scab.
Chemical ID: MESH:D008344
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Arg1multiple interactionsEXP 6480464CTD[Maneb co-treated with Paraquat] results in increased expression of ARG1 mRNA; [Paraquat co-treated with Maneb] results in increased expression of ARG1 mRNA; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ARG1 mRNA]PMID:29568078 PMID:32375810 PMID:34052309
Arg1decreases expressionISOARG1 (Homo sapiens)6480464CTDManeb results in decreased expression of ARG1 mRNAPMID:32194361
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