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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:52497
Term: maneb
Definition: A polymeric complex of manganese with the ethylene bis(dithiocarbamate) anionic ligand. An agrochemical fungicide, it is used to control a variety of diseases including blight, leaf spot, rust, downy mildew and scab.
Chemical ID: MESH:D008344
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7362186480464CTDManeb results in decreased expression of CYP2D22 protein

PMID:22334051
multiple interactionsISORGD:7362186480464CTDKetoconazole inhibits the reaction [Maneb results in decreased expression of CYP2D22 protein]

PMID:22334051
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.