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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1621607
Species: Mus musculus
RGD Object: Gene
Symbol: Mef2c
Name: myocyte enhancer factor 2C
Acc ID: CHEBI:52497
Term: maneb
Definition: A polymeric complex of manganese with the ethylene bis(dithiocarbamate) anionic ligand. An agrochemical fungicide, it is used to control a variety of diseases including blight, leaf spot, rust, downy mildew and scab.
Chemical ID: MESH:D008344
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mef2cmultiple interactionsISOMEF2C (Homo sapiens)6480464CTD[Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]] which results in increased metabolism of MEF2C protein; [Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]] which results in increased metabolism of MEF2C proteinPMID:24290359
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