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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308152
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Creb3l3
Name: cAMP responsive element binding protein 3-like 3
Acc ID: CHEBI:52392
Term: 2-arachidonoylglycerol
Definition: An endocannabinoid and an endogenous agonist of the cannabinoid receptors (CB1 and CB2). It is an ester formed from omega-6-arachidonic acid and glycerol.
Chemical ID: MESH:C094503
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Creb3l3increases expressionISOCREB3L3 (Homo sapiens)6480464CTDglyceryl 2-arachidonate results in increased expression of CREB3L3 mRNAPMID:23894352
Creb3l3increases expressionISOCreb3l3 (Mus musculus)6480464CTDglyceryl 2-arachidonate results in increased expression of CREB3L3 mRNAPMID:23894352
Creb3l3multiple interactionsISOCREB3L3 (Homo sapiens)6480464CTDglyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP27A1 promoter]; glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP7A1 promoter]; INS protein inhibits the reaction [glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP27A1 promoter]]; INS protein inhibits the reaction [glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP7A1 promoter]]; INS protein inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CREB3L3 mRNA]PMID:23894352
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