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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731911
Species: Mus musculus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:52289
Term: wortmannin
Definition: A delta-lactone that has formula C23H24O8.
Chemical ID: MESH:C009687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9decreases activityISOMMP9 (Homo sapiens)6480464CTDwortmannin results in decreased activity of MMP9 proteinPMID:22033475
Mmp9multiple interactionsISOMMP9 (Homo sapiens)6480464CTDwortmannin inhibits the reaction [fucoidan results in decreased expression of MMP9]; wortmannin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; wortmannin promotes the reaction [ovatodiolide results in decreased activity of MMP9 protein]PMID:22033475 PMID:23288142 PMID:24333868
Mmp9multiple interactionsISOMmp9 (Rattus norvegicus)6480464CTDwortmannin inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]PMID:20195827
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