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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620563
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lpar1
Name: lysophosphatidic acid receptor 1
Acc ID: CHEBI:52288
Term: 1-octadec-9-enoylglycero-3-phosphate
Definition: A 2-lysophosphatidic acid that has formula C21H41O7P.
Chemical ID: MESH:C032881
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lpar1increases response to substanceISOLPAR1 (Homo sapiens)6480464CTDLPAR1 protein results in increased susceptibility to lysophosphatidic acidPMID:16809448
Lpar1multiple interactionsISOLPAR1 (Homo sapiens)6480464CTDLPAR1 protein affects the reaction [lysophosphatidic acid results in increased stability of and affects the localization of NFE2L2 protein]; lysophosphatidic acid inhibits the reaction [CXCR1 protein binds to LPAR1 protein]; lysophosphatidic acid results in decreased expression of [CXCR1 protein binds to LPAR1 protein]PMID:16224106 PMID:25398768
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