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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11094
Species: Mus musculus
RGD Object: Gene
Symbol: Abcb4
Name: ATP-binding cassette, sub-family B member 4
Acc ID: CHEBI:52010
Term: chlorphenamine
Definition: A tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma.
Chemical ID: MESH:D002744
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb4decreases activityISOABCB4 (Homo sapiens)6480464CTDChlorpheniramine results in decreased activity of ABCB4 proteinPMID:28437613
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